Born Nov 20 1892 - Died Jun 19 1965
Extract Obtainable from the Mammalian Pancreas or from the Related Glands
in Fishes, Useful in the Treatment of Diabetes Mellitus, and a Method
of Preparing It
Isolated, Purified Insulin
Patent Number(s) 1,469,994
The process for producing enough pure insulin for clinical trials was
developed by James B. Collip, a biochemist who provided a key contribution
to the treatment of diabetes.
After Charles Best and Frederick Banting discovered insulin and proved
that it could save the lives of diabetics, they encountered trouble
finding ways to purify and extract the natural hormone. Collie solved
the problem by devising the first successful process that could remove
harmful impurities from insulin while retaining its lifesaving qualities.
Days after he produced a batch of his extract, it was used to save a
14 year old boy who was near death from the ravages of diabetes. Collie
went on to become a leading endocrinologist and a worldwide authority
on the properties of insulin.
Born in Belleville, Ontario, Collie earned his B.A. from Trinity College
in 1912 and his M.A. in 1913. He earned a Ph.D. in biochemistry from
the University of Toronto in 1916. He conducted research at the University
of Alberta, McGill University in Montreal, and the University of Western
Ontario. He received numerous professional awards and honorary degrees.